Article

Identifying a next-generation antimalarial trioxolane in a landscape of artemisinin partial resistance

2025-01-03

Abstract excerpt

For over two decades, artemisinin-based combination therapy (ACT) has been the standard of care for the treatment of uncomplicated falciparum malaria. However, artemisinin partial resistance (ART-R) is now prevalent in Southeast Asia and has emerged in eastern Africa, threatening ACT efficacy. Mechanistically, ART-R results from an endocytosis defect that limits concentrations of host-derived free heme in the para...

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Literature Corpus work: 567f0ad6-e6a3-5f0b-ab7d-391d38f04d28
DOI: 10.1101/2025.01.02.631109

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