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Whole Cell Phenotypic Screening Of MMV Pathogen Box identifies Specific Inhibitors of <i>Plasmodium falciparum</i> merozoite maturation and egress

2019-09-18

Abstract excerpt

We report a systematic, cellular phenotype-based antimalarial screening of the MMV Pathogen Box collection, which facilitated the identification of specific blockers of late stage intraerythrocytic Plasmodium falciparum maturation. First, from standard growth inhibition asays, we discovered 62 additional antimalarials ( EC 50 ≤ 10μM) over previously known antimalarial candidates from Pathogen Box. A total of 90...

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Literature Corpus work
5269ba61-3d14-5750-ac7f-2f4c0051e7ce
DOI
10.1101/772434
Open publication

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