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Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box

11 Jan 2021

Abstract excerpt

Abstract Chemical matter is needed to target the divergent biology associated with the different life cycle stages of Plasmodium . Here, we report the parallel de novo screening of the Medicines for Malaria Venture (MMV) Pandemic Response Box against Plasmodium asexual and liver stage parasites, stage IV/V gametocytes, gametes, oocysts and as endectocides. Unique chemotypes were identified with both multistage...

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PMID: 33431834
DOI: 10.1038/s41467-020-20629-8

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