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Aryl N-acetamide compounds exert antimalarial activity by acting as agonists of rhomboid protease <i>Pf</i> ROM8 and cation channel <i>Pf</i> CSC1

2025-03-19

Abstract excerpt

With resistance to current frontline antimalarials spreading globally, new drug candidates need to be discovered to populate the antimalarial drug development pipeline. We previously screened the Medicines for Malaria Venture Pathogen Box for compounds that prevent Plasmodium falciparum parasites from exiting and invading human erythrocytes, steps essential for the proliferation of parasites in the blood, which c...

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Identifiers and source

Literature Corpus work
7800cf15-036e-5597-aaf1-267e41fda97c
DOI
10.1101/2025.03.18.644039
Open publication

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