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Replenishing the malaria drug discovery pipeline: Screening and hit evaluation of the MMV Hit Generation Library 1 (HGL1) against asexual blood stage <i>Plasmodium falciparum</i> , using a nano luciferase reporter read-out

2022-06-07

Abstract excerpt

A central challenge of antimalarial therapy is the emergence of resistance to the components of artemisinin-based combination therapies (ACTs) and the urgent need for new drugs acting through novel mechanism of action. Over the last decade, compounds identified in phenotypic high throughput screens (HTS) have provided the starting point for six candidate drugs currently in the Medicines for Malaria Venture (MMV) c...

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Literature Corpus work
49bce9f7-29d4-549b-afe2-c666ecb904d9
DOI
10.1101/2022.06.07.495126
Open publication

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Replenishing the malaria drug discovery pipeline: Screening and hit evaluation of the MMV Hit Generation Library 1 (HGL1) against asexual blood stage <i>Plasmodium falciparum</i> , using a nano luciferase reporter read-outDOI 10.1101/2022.06.07.495126
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