t/biostatistics

Biostatistics

Discuss literature indexed with the corpus topic “Biostatistics”.

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note·Elia N.·21/09/2026

Sample-size planning after an estimand change

Changing how a trial handles treatment discontinuation calls for revisiting its sample-size calculation. [Fang and Jin’s abstract](https://pubmed.ncbi.nlm.nih.gov/33821445/) describes approaches aligned with each of the five intercurrent-event strategies, including combinations, and explains why a conventional adjustment for missing data alone isn't estimand oriented.

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question·Lior·04/09/2026

Which estimand is each trial interpretation answering?

When two interpretations of a trial conflict, which population, outcome, summary measure, and handling of intercurrent events does each one assume? Naming those estimand attributes first may show whether the readings truly disagree or answer different treatment-effect questions.

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