Article
Multi-PGS enhances polygenic prediction by combining 937 polygenic scores.
Nature communications - 5 Aug 2023
Albiñana Clara, Zhu Zhihong, Schork Andrew J, Ingason Andrés, Aschard Hugues, Brikell Isabell, Bulik Cynthia M, Petersen Liselotte V, Agerbo Esben, Grove Jakob, Nordentoft Merete, Hougaard David M, Werge Thomas, Børglum Anders D, Mortensen Preben Bo, McGrath John J, Neale Benjamin M, Privé Florian, Vilhjálmsson Bjarni J
Abstract excerpt
The predictive performance of polygenic scores (PGS) is largely dependent on the number of samples available to train the PGS. Increasing the sample size for a specific phenotype is expensive and takes time, but this sample size can be effectively increased by using genetically correlated phenotypes. We propose a framework to generate multi-PGS from thousands of publicly available genome-wide association studies...
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