Article

A unique malignant cell type per patient tumor is encoded in each cancer cell transcriptome.

2024-11-03

Abstract excerpt

Deciphering shared features between patients through unsupervised analyses of tumor single-cell transcriptomes is hindered by the predominant clustering of malignant cells based on the patient's tumor of origin. In contrast, cancer-associated non-malignant cells within tumors cluster according to their somatic cell type (e.g. macrophage, fibroblast, astrocyte), regardless of the individual patient. We investigated...

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Identifiers and source

Literature Corpus work: 555dfd64-054e-55bd-a934-515a2ea073a5
DOI: 10.1101/2024.10.30.620989

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