Cancer cell states and emergent properties of the dynamic tumor system.

Abstract excerpt

Phenotypic heterogeneity within malignant cells of a tumor is emerging as a key property of tumorigenesis. Recent work using single-cell transcriptomics has led to the identification of distinct cancer cell states across a range of cancer types, but their functional relevance and the advantage that they provide to the tumor as a system remain elusive. We present here a definition of cancer cell states in terms of...

Topics

• Biological Evolution
• Carcinogenesis
• Cell Transformation, Neoplastic
• Humans
• Mutation
• Neoplasms