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Surveying brain tumor heterogeneity by single-cell RNA-sequencing of multi-sector biopsies

29 May 2020

Abstract excerpt

Brain tumors are among the most challenging human tumors for which the mechanisms driving progression and heterogeneity remain poorly understood. We combined single-cell RNA-seq with multi-sector biopsies to sample and analyze single-cell expression profiles of gliomas from 13 Chinese patients. After classifying individual cells, we generated a spatial and temporal landscape of glioma that revealed the patterns...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34692159
DOI: 10.1093/nsr/nwaa099

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