Article

A Single-Cell Atlas of RNA Alternative Splicing in the Glioma-Immune Ecosystem

2025-03-30

Abstract excerpt

<h4>Summary</h4> Single-cell analysis has refined our understanding of cellular heterogeneity in glioma, yet RNA alternative splicing (AS)—a critical layer of transcriptome regulation—remains underexplored at single-cell resolution. Here, we present a pan-glioma single-cell AS analysis in both tumor and immune cells through integrating seven SMART-seq2 datasets of human gliomas. Our analysis reveals lineage-speci...

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Literature Corpus work: bf3f4455-45f6-5d8d-baa4-6d7d524a570e
DOI: 10.1101/2025.03.26.645511

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