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Article

Single-cell transcriptome analysis of lineage diversity in high-grade glioma

24 Jul 2018

Abstract excerpt

BACKGROUND: Despite extensive molecular characterization, we lack a comprehensive understanding of lineage identity, differentiation, and proliferation in high-grade gliomas (HGGs). METHODS: We sampled the cellular milieu of HGGs by profiling dissociated human surgical specimens with a high-density microwell system for massively parallel single-cell RNA-Seq. We analyzed the resulting profiles to identify...

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PMID: 30041684
DOI: 10.1186/s13073-018-0567-9

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