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Identification of malignant cells in single-cell transcriptomics data

22 Aug 2025

Abstract excerpt

Single-cell transcriptomics has significantly advanced our ability to uncover the cellular heterogeneity of tumors. A key challenge in single-cell transcriptomics is identifying cancer cells and, in particular, distinguishing them from non-malignant cells of the same cell lineage. Focusing on features that can be measured by single-cell transcriptomics, this review explores the molecular aberrations of cancer...

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PMID: 40846797
DOI: 10.1038/s42003-025-08695-4

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