Article

Resolving malignant cell heterogeneity from bulk tumor RNA-seq data with CDState

2025-03-07

Abstract excerpt

Intratumor transcriptional heterogeneity (ITTH), defined by the coexistence of diverse cell states within one tumor, complicates cancer treatment by contributing to variable therapeutic responses. Although single-cell RNA sequencing can resolve this complexity, its cost and technical demands limit its large-scale use. Bulk RNA-seq data provide a scalable alternative, but most deconvolution methods depend on predef...

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Literature Corpus work: 119ef87d-9ad4-59aa-a02b-f16bf532e92a
DOI: 10.1101/2025.03.01.641017

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