Article

The transcriptional hallmarks of intra-tumor heterogeneity across a thousand tumors

2021-12-20

Abstract excerpt

Each tumor contains malignant cells that differ in genotype, phenotype, and in their interactions with the tumor micro-environment (TME). This results in distinct integrated cellular states that govern intra-tumor heterogeneity (ITH), a central challenge of cancer therapeutics. Dozens of recent studies have begun to describe ITH by single cell RNA-seq, but each study typically profiledonly a small number of tumors...

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Literature Corpus work: c36fa5a3-02f0-5d67-9d31-330513acfcfd
DOI: 10.1101/2021.12.19.473368

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