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Serine/threonine protein kinase phosphorylation of DosR alters target gene transcription mechanics and regulates <i>Mycobacterium tuberculosis</i> sensitivity to nitric oxide stress

2025-09-03

Abstract excerpt

<h4>ABSTRACT</h4> Successful host colonization by bacterial pathogens requires appropriate response and adaptation to environmental signals encountered during infection, with two-component systems (TCSs) and serine/threonine protein kinases (STPKs) being two important signal transduction mechanisms. Mycobacterium tuberculosis (Mtb) possesses similar numbers of STPKs (11) and TCSs (12), but if and how these two r...

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Literature Corpus work
553d1a96-5bf7-503d-aed1-b2fde37f5f84
DOI
10.1101/2025.09.03.674086
Open publication

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