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Article

The DosR Regulon Modulates Adaptive Immunity and is Essential for <i>Mycobacterium tuberculosis</i> Persistence

2 Mar 2015

Abstract excerpt

RATIONALE: Hypoxia promotes dormancy by causing physiologic changes to actively replicating Mycobacterium tuberculosis. DosR controls the response of M. tuberculosis to hypoxia. OBJECTIVES: To understand DosR's contribution in the persistence of M. tuberculosis, we compared the phenotype of various DosR regulon mutants and a complemented strain to M. tuberculosis in macaques, which faithfully model M....

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PMID: 25730547
DOI: 10.1164/rccm.201408-1502oc

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