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Article

Unique Regulation of the DosR Regulon in the Beijing Lineage of Mycobacterium tuberculosis.

Journal of bacteriology - 15 Jan 2017

Domenech Pilar, Zou Jason, Averback Alexandra, Syed Nishath, Curtis Daniele, Donato Samuel, Reed Michael B

Abstract excerpt

The DosR regulon, a set of 48 genes normally expressed in Mycobacterium tuberculosis under conditions that inhibit aerobic respiration, is controlled via the DosR-DosS/DosT two-component system. While the regulon requires induction in most M. tuberculosis isolates, for members of the Beijing lineage, its expression is uncoupled from the need for signaling. In our attempts to understand the mechanistic basis for...

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Identifiers

PMID: 27799329
DOI: 10.1128/JB.00696-16
PMCID: PMC5198487

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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