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Article

Cmr is a redox-responsive regulator of DosR that contributes to M. tuberculosis virulence

28 Apr 2017

Abstract excerpt

Mycobacterium tuberculosis (MTb) is the causative agent of pulmonary tuberculosis (TB). MTb colonizes the human lung, often entering a non-replicating state before progressing to life-threatening active infections. Transcriptional reprogramming is essential for TB pathogenesis. In vitro, Cmr (a member of the CRP/FNR super-family of transcription regulators) bound at a single DNA site to act as a dual regulator of...

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PMID: 28482027
DOI: 10.1093/nar/gkx406

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