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Article

M. tuberculosis PrrA binds the dosR promoter and regulates mycobacterial adaptation to hypoxia.

Tuberculosis (Edinburgh, Scotland) - 1 Sept 2024

Haller Yannik A, Jiang Jiapei, Wan Zijian, Childress Alexia, Wang Shaopeng, Haydel Shelley E

Abstract excerpt

The PrrAB two-component system (TCS) is essential for Mycobacterium tuberculosis viability. Previously, it was demonstrated that PrrA binds DNA in the absence of PrrB-mediated transphosphorylation and that non-cognate serine/threonine-kinases phosphorylate PrrA threonine-6 (T6). Therefore, we investigated the differential binding affinity and regulatory properties of the M. tuberculosis-derived wild-type PrrA,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Promoter Regions, Genetic

Source

Identifiers

PMID: 38885567
DOI: 10.1016/j.tube.2024.102531

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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