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Article

Targeting multiple response regulators of Mycobacterium tuberculosis augments the host immune response to infection.

Scientific reports - 16 May 2016

Banerjee Srijon Kaushik, Kumar Manish, Alokam Reshma, Sharma Arun Kumar, Chatterjee Ayan, Kumar Ranjeet, Sahu Sanjaya Kumar, Jana Kuladip, Singh Ramandeep, Yogeeswari Perumal, Sriram Dharmarajan, Basu Joyoti, Kundu Manikuntala

Abstract excerpt

The genome of M. tuberculosis (Mtb) encodes eleven paired two component systems (TCSs) consisting of a sensor kinase (SK) and a response regulator (RR). The SKs sense environmental signals triggering RR-dependent gene expression pathways that enable the bacterium to adapt in the host milieu. We demonstrate that a conserved motif present in the C-terminal domain regulates the DNA binding functions of the OmpR...

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Identifiers

PMID: 27181265
DOI: 10.1038/srep25851
PMCID: PMC4867592

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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