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Article

Mycobacterium tuberculosis supports protein tyrosine phosphorylation.

Proceedings of the National Academy of Sciences of the United States of America - 24 Jun 2014

Kusebauch Ulrike, Ortega Corrie, Ollodart Anja, Rogers Richard S, Sherman David R, Moritz Robert L, Grundner Christoph

Abstract excerpt

Reversible protein phosphorylation determines growth and adaptive decisions in Mycobacterium tuberculosis (Mtb). At least 11 two-component systems and 11 Ser/Thr protein kinases (STPKs) mediate phosphorylation on Asp, His, Ser, and Thr. In contrast, protein phosphorylation on Tyr has not been described previously in Mtb. Here, using a combination of phospho-enrichment and highly sensitive mass spectrometry, we...

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Identifiers

PMID: 24927537
DOI: 10.1073/pnas.1323894111
PMCID: PMC4078798

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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