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Article

Rv3133c/ <i>dosR</i> is a transcription factor that mediates the hypoxic response of <i>Mycobacterium tuberculosis</i>

9 Apr 2003

Abstract excerpt

Unlike many pathogens that are overtly harmful to their hosts, Mycobacterium tuberculosis can persist for years within humans in a clinically latent state. Latency is often linked to hypoxic conditions within the host. Among M. tuberculosis genes induced by hypoxia is a putative transcription factor, Rv3133c/DosR. We performed targeted disruption of this locus followed by transcriptome analysis of wild-type and...

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PMID: 12694625
DOI: 10.1046/j.1365-2958.2003.03474.x

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