Article

B-cell repertoire sequencing reveals frequent rearrangements of IGHD5-5 in patients with systemic sclerosis

2025-12-08

Abstract excerpt

<title>Abstract</title> <p>Systemic sclerosis (SSc) is an autoimmune disorder marked by fibrosis of the skin and internal organs, with B cells increasingly recognized as key players in its pathogenesis. However, the characteristics of the B cell receptor (BCR) repertoire in SSc remain insufficiently defined. In this study, we performed high-throughput sequencing of immunoglobulin heavy chain genes in 15 female an...

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Literature Corpus work: 5536aba0-0553-5e92-b2cc-9281610ac28a
DOI: 10.21203/rs.3.rs-7604828/v1

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