Article

Dynamics of the Human Antibody Repertoire following B-cell Depletion in Systemic Sclerosis

2017-05-18

Abstract excerpt

Systemic sclerosis with pulmonary arterial hypertension (SSc-PAH) is a debilitating and frequently lethal disease of unknown cause lacking effective treatment options. Lymphocyte anomalies and autoantibodies observed in systemic sclerosis have suggested an autoimmune character. Here we study the clonal structure of the B-cell repertoire in SSc-PAH using immunoglobulin heavy-chain sequencing before and after B-cell...

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Literature Corpus work: 98137384-9f08-5253-adfc-7239823f0e4e
DOI: 10.1101/139758

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