Article

Public B cell receptor clonotypes bridge chronic autoimmunity and lymphomagenesis

2026-06-02

Abstract excerpt

<title>Abstract</title> <p>The genetic architecture of the antibody repertoires in chronic autoimmunity, and its relationship to B cell malignancy risk, remains incompletely defined. Using deep B cell receptor (BCR) heavy-chain sequencing from 20 Sjögren's syndrome (SS) patients (> 7 million unique sequences), compared to 11 age- and sex-matched healthy controls and 330 blood samples from 64 healthy donors, we id...

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Literature Corpus work: fe051e2b-255d-5c7f-9474-7ff484305960
DOI: 10.21203/rs.3.rs-9861420/v1

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