Article

Multimodal repertoire analysis unveils B cell biology in immune-mediated diseases

2022-01-05

Abstract excerpt

<h4>Objectives</h4> Despite the involvement of B cells in the pathogenesis of immune-mediated diseases, biological mechanisms underlying their function are scarcely understood. To overcome this gap, here we constructed and investigated a large-scale repertoire catalog of five B cell subsets of immune-mediated disease patients. <h4>Methods</h4> We mapped B cell receptor regions from RNA sequencing data of sorted B...

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Literature Corpus work: 223408e7-369b-5d82-9257-3768d2f3544c
DOI: 10.1101/2022.01.04.22268769

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