Article
Composition and variation analysis of the TCR β-chain CDR3 repertoire in systemic lupus erythematosus using high-throughput sequencing.
Molecular immunology - 1 Oct 2015
Sui Weiguo, Hou Xianliang, Zou Guimian, Che Wenti, Yang Ming, Zheng Can, Liu Fuhua, Chen Peng, Wei Xiaolian, Lai Liusheng, Dai Yong
Abstract excerpt
The ability of T lymphocytes to mount an immune response against a diverse array of pathogens is primarily conveyed by the amino acid (aa) sequence of the hypervariable complementarity-determining region 3 (CDR3) segments of the T cell receptor (TCR). In this study, we used a combination of multiplex-PCR, Illumina sequencing and IMGT/HighV-QUEST for a standardized analysis of the characteristics and polymorphisms...
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