Dynamics of the human antibody repertoire after B cell depletion in systemic sclerosis

Abstract excerpt

) proportion with reduced mutation loads and an expanded proportion of highly antibody-secreting cells. Disease signatures pertaining to IGHV2-5 segment usage, IgD proportions, and mutation loads were temporarily reversed after B cell depletion. Analyzing the time course of B cell depletion, we find that the kinetics of naïve replenishment are predictable from baseline measurements alone, that release of plasma...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Eosinophilic Disorders and Syndromes
• Share to Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
• Share to Systemic Sclerosis and Related Diseases