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Article

Multimodal Single-Cell Sequencing of B Cells in Primary Sjögren's Syndrome.

Arthritis & rheumatology (Hoboken, N.J.) - 1 Feb 2024

Arvidsson Gustav, Czarnewski Paulo, Johansson Alina, Raine Amanda, Imgenberg-Kreuz Juliana, Nordlund Jessica, Nordmark Gunnel, Syvänen Ann-Christine

Abstract excerpt

OBJECTIVE: B cells are important in the pathogenesis of primary Sjögren's syndrome (pSS). Patients positive for Sjögren's syndrome antigen A/Sjögren syndrome antigen B (SSA/SSB) autoantibodies are more prone to systemic disease manifestations and adverse outcomes. We aimed to determine the role of B cell composition, gene expression, and B cell receptor usage in pSS subgroups stratified for SSA/SSB antibodies....

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PMID: 37610265
DOI: 10.1002/art.42683

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