Article

TEX44 CPT1B Axis Regulates Mitochondrial Sheath Assembly and Fatty Acid Oxidation in Sperm

2025-05-08

Abstract excerpt

<title>Abstract</title> <p>Mitochondrial fatty acid β-oxidation (FAO) is critical for cellular energy homeostasis, yet its regulatory role in sperm remains elusive. Whole-exome sequencing of 800 asthenozoospermia patients revealed biallelic TEX44 mutations in six individuals with defective mitochondrial sheath assembly and impaired motility. In Tex44 knockout mice, TEX44 interacts with CPT1B to form a mitochondri...

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Literature Corpus work: 5502779f-063a-52b4-bf4a-61736849c8ad
DOI: 10.21203/rs.3.rs-5642169/v1

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