Article

Tafazzin-Mediated Cardiolipin Remodeling Controls Metabolic Stress Response and Effector Function of Inflammatory T Cells

2025-08-28

Abstract excerpt

<h4>SUMMARY</h4> Clonal expansion and effector differentiation of T cells require extensive metabolic reprogramming. This includes the restructuring of the inner mitochondrial membrane (IMM) to enhance respiration by increasing chemiosmotic coupling efficiency. Cardiolipin, a unique phospholipid that is exclusively synthesized and localized in the IMM, modulates the biophysical properties of the electron transpor...

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Literature Corpus work: 40a45870-dc70-549a-bf06-0210c594863c
DOI: 10.1101/2025.08.25.672061

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