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Article

Impact of DNAH3 deficiency on sperm energy metabolism and motility leading to asthenozoospermia

7 Jan 2025

Abstract excerpt

Asthenozoospermia, a prevalent contributor to male infertility, exhibits a multifaceted pathogenesis. This study identified a significant downregulation in sperm dynein heavy chain 3 (DNAH3) protein levels in individuals with asthenozoospermia. To elucidate the role of DNAH3 in asthenozoospermia, we constructed Dnah3-knockout mice, which exhibited asthenozoospermia and sterility. The sperm motility of...

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PMID: 39774634
DOI: 10.1093/biolre/ioaf008

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