Article

Sperm-specific COX6B2 enhances oxidative phosphorylation, proliferation, and survival in lung adenocarcinoma

2020-04-11

Abstract excerpt

<h4>ABSTRACT</h4> Cancer testis antigens (CTAs) are genes whose expression is normally restricted to the testis but anomalously activated in cancer. In sperm, a number of CTAs promote energy generation, however whether these proteins contribute to tumor cell metabolism is not understood. Here we describe COX6B2, a sperm-specific component of cytochrome c oxidase (complex IV). COX6B2 is frequently expressed in hum...

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Literature Corpus work: 0d135f11-aa43-55c3-8b9f-ac72d520f471
DOI: 10.1101/2020.04.09.030403

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