Article

Retrograde mitochondrial signaling governs the identity and maturity of metabolic tissues

2022-08-03

Abstract excerpt

<h4>ABSTRACT</h4> Mitochondrial damage is a hallmark of metabolic diseases, including diabetes and metabolic dysfunction-associated steatotic liver disease, yet the consequences of impaired mitochondria in metabolic tissues are often unclear. Here, we report that dysfunctional mitochondrial quality control engages a retrograde (mitonuclear) signaling program that impairs cellular identity and maturity across mult...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6f1a0f2c-5388-599e-a932-642fd6fd10ea
DOI: 10.1101/2022.08.02.502357

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Retrograde mitochondrial signaling governs the identity and maturity of metabolic tissuesDOI 10.1101/2022.08.02.502357Read

Retrograde mitochondrial signaling governs the identity and maturity of metabolic tissuesSemantic proximity Read

Limitations in PPAR⍺-dependent mitochondrial programming restrain the differentiation of human stem cell-derived β cellsSemantic proximity Read

Mitochondrial transport, partitioning, and quality control at the heart of cell proliferation and fate acquisition.Semantic proximity Read

AFF3 and BACH2 are master regulators of metabolic inflexibility, β/α-cell transition, and dedifferentiation in type 2 diabetesSemantic proximity Read

The Mighty Mitochondria Are Unifying Organelles and Metabolic Hubs in Multiple Organs of Obesity, Insulin Resistance, Metabolic Syndrome, and Type 2 Diabetes: An Observational Ultrastructure StudySemantic proximity Read

Mitochondrial Heterogeneity in Metabolic DiseasesSemantic proximity Read

Mitochondrial Dynamics in Type 2 Diabetes and CancerSemantic proximity Read

Bcl-xL restricts transcriptional, morphological and functional decompensation of β-cell mitochondria under chronic glucose excessSemantic proximity Read

Mitochondrial Dysregulation in the Pathogenesis of Diabetes: Potential for Mitochondrial Biogenesis-Mediated InterventionsSemantic proximity Read

FoxM1 coordinates cell division, protein synthesis, and mitochondrial activity in a subset of β cells during acute metabolic stressSemantic proximity Read

Mitochondrial regulation in human pluripotent stem cells during reprogramming and β cell differentiationSemantic proximity Read

Mitofusins <i>Mfn1</i> and <i>Mfn2</i> are required to preserve glucose-but not incretin- stimulated beta cell connectivity and insulin secretionSemantic proximity Read