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The TEX44-CPT1B axis regulates mitochondrial sheath assembly and fatty acid oxidation in sperm

23 Aug 2025

Abstract excerpt

Mitochondrial fatty acid β-oxidation (FAO) is essential for energy production and cellular homeostasis, yet its role in sperm function has remained unclear. Through whole-exome sequencing (WES) of 800 patients with asthenozoospermia, we identified biallelic Testis-Expressed Protein 44 (TEX44) variants in six individuals, all of whom exhibited defective mitochondrial sheath assembly and impaired sperm motility....

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PMID: 40849303
DOI: 10.1038/s41467-025-63280-x

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