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Article

STK33 Phosphorylates Fibrous Sheath Protein AKAP3/4 to Regulate Sperm Flagella Assembly in Spermiogenesis

3 May 2023

Abstract excerpt

Spermatogenesis defects are important for male infertility; however, the etiology and pathogenesis are still unknown. Herein, we identified two loss-of-function mutations of STK33 in seven individuals with non-obstructive azoospermia. Further functional studies of these frameshift and nonsense mutations revealed that Stk33 -/KI male mice were sterile, and Stk33 -/KI sperm were abnormal with defects in the...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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Identifiers

PMID: 37146716
DOI: 10.1016/j.mcpro.2023.100564

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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STK33 Phosphorylates Fibrous Sheath Protein AKAP3/4 to Regulate Sperm Flagella Assembly in SpermiogenesisPMID 37146716Read ↗

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