Article
Quantitative Proteomics of the Cancer Cell Line Encyclopedia.
Cell - 23 Jan 2020
Nusinow David P, Szpyt John, Ghandi Mahmoud, Rose Christopher M, McDonald E Robert, Kalocsay Marian, Jané-Valbuena Judit, Gelfand Ellen, Schweppe Devin K, Jedrychowski Mark, Golji Javad, Porter Dale A, Rejtar Tomas, Wang Y Karen, Kryukov Gregory V, Stegmeier Frank, Erickson Brian K, Garraway Levi A, Sellers William R, Gygi Steven P
Abstract excerpt
Proteins are essential agents of biological processes. To date, large-scale profiling of cell line collections including the Cancer Cell Line Encyclopedia (CCLE) has focused primarily on genetic information whereas deep interrogation of the proteome has remained out of reach. Here, we expand the CCLE through quantitative profiling of thousands of proteins by mass spectrometry across 375 cell lines from diverse...
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