Article

Multi-omics characterization of interaction-mediated control of human protein abundance levels

2018-12-17

Abstract excerpt

Proteogenomic studies of cancer samples have shown that copy number variation can be attenuated at the protein level, for a large fraction of the proteome, likely due to the degradation of unassembled protein complex subunits. Such interaction mediated control of protein abundance remains poorly characterized. To study this we compiled genomic, (phospho)proteomic and structural data for hundreds of cancer samples...

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Literature Corpus work: 992930c4-ce79-5cef-a08c-970476d83924
DOI: 10.1101/499434

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