Article
Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes.
Nature - 1 Nov 2023
Zhang Fan, Jonsson Anna Helena, Nathan Aparna, Millard Nghia, Curtis Michelle, Xiao Qian, Gutierrez-Arcelus Maria, Apruzzese William, Watts Gerald F M, Weisenfeld Dana, Nayar Saba, Rangel-Moreno Javier, Meednu Nida, Marks Kathryne E, Mantel Ian, Kang Joyce B, Rumker Laurie, Mears Joseph, Slowikowski Kamil, Weinand Kathryn, Orange Dana E, Geraldino-Pardilla Laura, Deane Kevin D, Tabechian Darren, Ceponis Arnoldas, Firestein Gary S, Maybury Mark, Sahbudin Ilfita, Ben-Artzi Ami, Mandelin Arthur M, Nerviani Alessandra, Lewis Myles J, Rivellese Felice, Pitzalis Costantino, Hughes Laura B, Horowitz Diane, DiCarlo Edward, Gravallese Ellen M, Boyce Brendan F, Moreland Larry W, Goodman Susan M, Perlman Harris, Holers V Michael, Liao Katherine P, Filer Andrew, Bykerk Vivian P, Wei Kevin, Rao Deepak A, Donlin Laura T, Anolik Jennifer H, Brenner Michael B, Raychaudhuri Soumya
Abstract excerpt
Rheumatoid arthritis is a prototypical autoimmune disease that causes joint inflammation and destruction1. There is currently no cure for rheumatoid arthritis, and the effectiveness of treatments varies across patients, suggesting an undefined pathogenic diversity1,2. Here, to deconstruct the cell states and pathways that characterize this pathogenic heterogeneity, we profiled the full spectrum of cells in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.