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Population-level single-cell genomics reveals conserved gene programs in systemic juvenile idiopathic arthritis

21 Sept 2023

Abstract excerpt

Systemic autoimmune and autoinflammatory diseases are characterized by genetic and cellular heterogeneity. While current single-cell genomics methods provide insights into known disease subtypes, these analysis methods do not readily reveal novel cell-type perturbation programs shared among distinct patient subsets. Here, we performed single-cell RNA-Seq of PBMCs of patients with systemic juvenile idiopathic...

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PMID: 37733441
DOI: 10.1172/jci166741

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