Article
On cross-ancestry cancer polygenic risk scores.
PLoS genetics - 1 Sept 2021
Fritsche Lars G, Ma Ying, Zhang Daiwei, Salvatore Maxwell, Lee Seunggeun, Zhou Xiang, Mukherjee Bhramar
Abstract excerpt
Polygenic risk scores (PRS) can provide useful information for personalized risk stratification and disease risk assessment, especially when combined with non-genetic risk factors. However, their construction depends on the availability of summary statistics from genome-wide association studies (GWAS) independent from the target sample. For best compatibility, it was reported that GWAS and the target sample...
Topics
- Breast Neoplasms
- Female
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Multifactorial Inheritance