Article
Generalizability of Polygenic Risk Scores for Breast Cancer Among Women With European, African, and Latinx Ancestry.
JAMA network open - 2 Aug 2021
Liu Cong, Zeinomar Nur, Chung Wendy K, Kiryluk Krzysztof, Gharavi Ali G, Hripcsak George, Crew Katherine D, Shang Ning, Khan Atlas, Fasel David, Manolio Teri A, Jarvik Gail P, Rowley Robb, Justice Ann E, Rahm Alanna K, Fullerton Stephanie M, Smoller Jordan W, Larson Eric B, Crane Paul K, Dikilitas Ozan, Wiesner Georgia L, Bick Alexander G, Terry Mary Beth, Weng Chunhua
Abstract excerpt
Importance: Multiple polygenic risk scores (PRSs) for breast cancer have been developed from large research consortia; however, their generalizability to diverse clinical settings is unknown. Objective: To examine the performance of previously developed breast cancer PRSs in a clinical setting for women of European, African, and Latinx ancestry. Design, Setting, and Participants: This cohort study using the...
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