Predictive performance of breast cancer polygenic risk scores from diverse ancestries: a prospective study in Japanese women.

doi:10.1186/s13058-026-02256-1

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Predictive performance of breast cancer polygenic risk scores from diverse ancestries: a prospective study in Japanese women.

Breast cancer research : BCR - 28 Apr 2026

Hara Megumi, Hachiya Tsuyoshi, Furukawa Takuma, Nishida Yuichiro, Tanaka Keitaro, Shimanoe Chisato, Otonari Jun, Ikezaki Hiroaki, Wakai Kenji, Matsunaga Takashi, Ito Hidemi, Yamamoto Sayaka, Michihata Nobuaki, Nakamura Yohko, Tanoue Shiroh, Hidaka Yoshifumi, Nishiyama Takeshi, Nakagawa Hiroko, Takashima Naoyuki, Matsui Daisuke, Kuriki Kiyonori, Miura Katsuyuki, Matsui Kenji, Watanabe Takeshi, Watanabe Kengo, Kageyama Itsuki, Nakatochi Masahiro, Momozawa Yukihide, Okada Rieko, Koyanagi Yuriko N, Oze Isao, Matsuo Keitaro

Abstract excerpt

BACKGROUND: Polygenic risk scores (PRSes) have emerged as promising tools for stratifying breast cancer risk on the basis of genomic data. However, PRSes developed in one ancestral population may vary in predictive performance when applied to a different population. This study aimed to evaluate the utility of six breast cancer PRSes developed via European and East Asian genome-wide association studies (GWASes) in...

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PMID: 42050630
DOI: 10.1186/s13058-026-02256-1
PMCID: PMC13270709

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