Article

The dynamics of prion spreading is governed by the interplay between the non-linearities of tissue response and replication kinetics

2024-05-01

Abstract excerpt

<h4>Summary</h4> Prion diseases, or Transmissible Spongiform Encephalopathies (TSE), are neurodegenerative disorders caused by the accumulation of misfolded conformers (PrP Sc ) of the cellular prion protein (PrP C ). During the pathogenesis, the PrP Sc seeds disseminate in the central nervous system and convert PrP C leading to the formation of insoluble assemblies. As for conventional infectious diseases, v...

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Literature Corpus work: 54ae7221-3088-5fb4-8d56-df018692bded
DOI: 10.1101/2024.05.01.592001

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