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Article

Prion replication environment defines the fate of prion strain adaptation.

PLoS pathogens - 1 Jun 2018

Katorcha Elizaveta, Gonzalez-Montalban Nuria, Makarava Natallia, Kovacs Gabor G, Baskakov Ilia V

Abstract excerpt

The main risk of emergence of prion diseases in humans is associated with a cross-species transmission of prions of zoonotic origin. Prion transmission between species is regulated by a species barrier. Successful cross-species transmission is often accompanied by strain adaptation and result in stable changes of strain-specific disease phenotype. Amino acid sequences of host PrPC and donor PrPSc as well as...

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Identifiers

PMID: 29928047
DOI: 10.1371/journal.ppat.1007093
PMCID: PMC6013019

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