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Mathematical Modeling of Protein Misfolding Mechanisms in Neurological Diseases: A Historical Overview

2 Feb 2018

Abstract excerpt

Protein misfolding refers to a process where proteins become structurally abnormal and lose their specific 3-dimensional spatial configuration. The histopathological presence of misfolded protein (MP) aggregates has been associated as the primary evidence of multiple neurological diseases, including Prion diseases, Alzheimer's disease, Parkinson's disease, and Creutzfeldt-Jacob disease. However, the exact...

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PMID: 29456521
DOI: 10.3389/fneur.2018.00037

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