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In vitro generation of highly infectious recombinant prions adopting structural architectures of bona fide prions

2026-03-12

Abstract excerpt

<title>Abstract</title> <p>Prions are the protein-only infectious agents responsible for prion diseases. Recent cryo-EM studies have revealed that brain-derived prions adopt Parallel In-Register Intermolecular β-Sheet (PIRIBS) structures and share a remarkably similar global folding architecture, characterized by an overall V shape composed of distinct N-terminal and C-terminal lobes. Despite this advance, the mo...

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Literature Corpus work
e10d277d-cb58-5dbb-bb7d-c22d9508cad7
DOI
10.21203/rs.3.rs-8875077/v1
Open publication

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In vitro generation of highly infectious recombinant prions adopting structural architectures of bona fide prionsDOI 10.21203/rs.3.rs-8875077/v1
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