Article

Full Atomistic Model of Prion Structure and Conversion

2018-12-22

Abstract excerpt

Prions are unusual protein assemblies that propagate their conformationally-encoded information in absence of nucleic acids. The first prion identified, the scrapie isoform (PrP Sc ) of the cellular prion protein (PrP C ), is the only one known to cause epidemic and epizootic episodes(1). Most aggregates of other misfolding-prone proteins are amyloids, often arranged in a Parallel-In-Register-β-Sheet (PIRIBS)(2)...

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Literature Corpus work: fca24a3d-6866-573d-b276-ec429ae983dd
DOI: 10.1101/505271

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