Article

Direct Observation of Competing Prion Protein Fibril Populations with Distinct Structures and Kinetics

2022-08-13

Abstract excerpt

<h4>Summary</h4> In prion diseases, fibrillar assemblies of misfolded prion protein (PrP) self-propagate by incorporating PrP monomers. Using total internal reflection and transient amyloid binding super-resolution microscopy, our study analyses elongation of single PrP fibrils to reveal polymorphic populations, featuring structural and dynamic heterogeneity similar to prion strains, which were previously hidden...

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Literature Corpus work: 43ff4235-0406-5413-9ca8-bd5196a98307
DOI: 10.1101/2022.08.10.503301

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